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Oleksandr Usyk bout at the division is in jeopardy after Saturdays opponent Tyrone Spong returned a negative doping test, says promoter Eddie Hearn.
Usyk, 32, gathered all of four world titles in his move and cruiserweight up a division has been anticipated.
But Surinamese-Dutch fighter Spongs position is in doubt after Voluntary Anti-Doping Association (Vada) testing.
Weve book opponents standing , tweeted Hearn.
Weve been approached by Vada to inform us that theres been an adverse finding in Tyrone Spongs evaluation. Its been delivered to the State of Illinois commission.
Hearn said therell be an upgrade on Tuesday.
When he defended all four world cruiserweight titles usyk is scheduled to face Spong in the Wintrust Arena of Chicago since quitting Britains Tony Bellew in November.
Spong, 34, spent a lot of his combat career in mixed martial arts and competed before winning his first 14 struggles as a boxer in kickboxing.
Vada requires fighters or promoters to pay for testing for the length of a fight build-up and works in boxing and MMA. It said Spong was a part of its testing programme on 20 September.
The Las Vegas-based Vada has been responsible for tests which resulted in the likes of Western Jarrell Miller and has made a glowing reputation in boxing and Mexicos SaulCanelo Alvarez.
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