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After Saturdays opponent Tyrone Spong returned an adverse doping test oleksandr Usyk bout in the division is in jeopardy, says promoter Eddie Hearn.
Usyk, 32, gathered all four world titles at his move and cruiserweight up a division has been highly anticipated.
However, Surinamese-Dutch fighter Spongs place is in doubt after Voluntary Anti-Doping Association (Vada) testing.
Weve book competitions standing by, tweeted Hearn.
Weve been contacted by Vada to inform us that there has been an adverse finding in Tyrone Spongs evaluation. Its been delivered into the State of Illinois commission.
Hearn said there will be an upgrade on Tuesday.
When he defended all four world cruiserweight titles usyk is scheduled to confront Spong in the Wintrust Arena of Chicago in his first bout since quitting Britains Tony Bellew in November.
Spong also competed in kickboxing before winning his first 14 struggles as a boxer and spent much of his combat career in martial arts.
Vada needs promoters or fighters to pay for testing for the length of a fight build-up and functions in MMA and boxing. It stated Spong was part of its testing programme on 20 September.
Even the Las Vegas-based Vada has made a reputation in boxing and was accountable for evaluations which caused the likes of heavyweight Jarrell Miller along with Mexicos SaulCanelo Alvarez facing bans.
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