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Scotland head coach Gregor Townsend has created 14 changes for the World Cup meeting of Wednesday with Russia.
Winger Darcy Graham is the only player retained from the starting XV that defeated Samoa.
Experienced flanker John Barclay contributes to lead the side having been dropped to Ireland after the opening loss.
Key players have been rested for a potential winner-takes-all meeting Pool A leaders Japan on Sunday.
Scotland want a bonus-point win over Russia to enter the final group game four factors.
Center Pete Horne, full-back Blair Kinghorn, lock hooker George Turner and Ben Toolis can make their first appearances in Japan, while the Horne brother starts at scrum-half after coming off the bench against Samoa.
He joins with all star fly-half Finn Russell among those held in reserve for the weekend, with Glasgow Warriors team-mate Adam Hastings.
Also a replacement hooker in the first two games, fraser Brown, is chosen from the rear row, together with Barclay and Ryan Wilson.
First and foremost weve picked a group we believe is capable of beating an increasingly remarkable and combative Russia side, that want to complete their Pool campaign on a top, said Townsend.
Any successful World Cup campaign is constructed on a squad effort and those gamers who didnt get the chance to begin against Samoa actually helped supply that team with an excellent week of preparation.
Now it is their opportunity to get trapped into our next major game.
Russia, ranked 20th in the world, are with no stage in Japan following three defeats.
Scotland: Kinghorn; Seymour, Taylor Horne, Graham; G Horne, Hastings; Reid, Turner, Turner Cummings, Toolis, Barclay, Brown, Wilson.
Replacements: McInally Nel, Gilchrist, Bradbury Pyrgos, Harris.
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